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FI6 is an antibody that targets a protein found on the surface of all influenza A viruses called hemagglutinin.〔(BBC: 'Super antibody' fights off flu )〕〔(Independent: Scientists hail the prospect of a universal vaccine for flu )〕〔(Huffington Post: Universal Flu Vaccine On The Horizon: Researchers Find 'Super Antibody' )〕 FI6 is the only known antibody found to bind all 16 subtypes of the influenza A virus hemagglutinin and is hoped to be useful for a universal influenza virus therapy.〔〔〔 The antibody binds to the F domain HA trimer, and prevents the virus from attaching to the host cell. The antibody has been refined in order to remove any excess, unstable mutations that could negatively affect its neutralising ability, and this new version of the antibody has been termed "FI6v3"〔(Science Magazine: A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins )〕 ==Research== Researchers from Britain and Switzerland have found antibodies that work in Group 1 influenza A viruses or against most Group 2 viruses, but not against both. This team developed a method using single-cell screening to test very large numbers of human plasma cells, to increase their odds of finding an antibody even if it was extremely rare.〔 When they identified FI6, they injected it into mice and ferrets and found that it protected the animals against infection by either a Group 1 or Group 2 influenza A virus.〔(Reuters: Flu "super antibody" may bring universal shot closer )〕 Scientists screened 104,000 peripheral-blood plasma cells from eight recently infected or vaccinated donors for antibodies that recognize each of three diverse influenza strains: H1N1 (swine-origin) and H5N1 and H7N7 (highly pathogenic avian influenzas.) From one donor, they isolated four plasma cells that produced an identical antibody, which they called FI6.This antibody binds all 16 HA subtypes, neutralizes infection, and protects mice and ferrets from lethal infection. The most broadly reactive antibodies that had previously been discovered recognized either one group of HA subtypes or the other, highlighting how remarkable FI6 is in its ability to target the gamut of influenza subtypes.〔(The New England Journal of Medicine: Stalking Influenza Diversity with a Universal Antibody )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「FI6 (antibody)」の詳細全文を読む スポンサード リンク
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